A cooperative and specific DNA-binding mode of HIV-1 integrase depends on the nature of the metallic cofactor and involves the zinc-containing N-terminal domain

Kevin Carayon (1) , Herve Leh (2) , Etienne Henry (3) , Françoise Simon (4) , Jean-François Mouscadet (1) , Eric Deprez (1)

1 LBPA - Laboratoire de Biologie et de Pharmacologie Appliquée
2 Bioalliancepharma
3 LM2E - Laboratoire de Microbiologie des Environnements Extrêmophiles
4 LBD - Laboratoire de Biologie du Développement

Domaines: Biophysique

Kevin Carayon, Herve Leh, Etienne Henry, Françoise Simon, Jean-François Mouscadet, et al.. A cooperative and specific DNA-binding mode of HIV-1 integrase depends on the nature of the metallic cofactor and involves the zinc-containing N-terminal domain. Nucleic Acids Research, 2010, 38 (11), pp.3692-3708. ⟨10.1093/nar/gkq087⟩. ⟨hal-02350642⟩