Association of hypertension with coronary artery disease onset in the Lebanese population.

Aline Milane (1) , Jad Abdallah (1) , Roy Kanbar (1) , Georges Khazen (2) , Michella Ghassibe-Sabbagh (3) , Angelique K. Salloum (3) , Sonia Youhanna (3) , Aline Saad (1) , Hamid El Bayeh (3) , Elie Chammas (3) , Daniel E. Platt (4) , Jörg Hager (5) , Dominique Gauguier (6, 7) , Pierre Zalloua (3, 8) , Antoine Abchee (9)

1 School of Pharmacy
2 School of Arts and Sciences
3 Gilbert and Rose-Marie Chagoury School of Medicine [Lebanese American University]
4 Bioinformatics and Pattern Discovery
5 IG - Institut de Génomique d'Evry
6 CRC (UMR_S 872) - Centre de Recherche des Cordeliers
7 The Wellcome Trust Centre for Human Genetics [Oxford]
8 Department of Environmental Health
9 Department of Internal Medicine

The onset of coronary artery disease (CAD) is influenced by cardiovascular risk factors that often occur in clusters and may build on one another. The objective of this study is to examine the relationship between hypertension and CAD age of onset in the Lebanese population. This retrospective analysis was performed on data extracted from Lebanese patients (n = 3,753). Logistic regression examined the association of hypertension with the age at CAD diagnosis after controlling for other traditional risk factors. The effect of antihypertensive drugs and lifestyle changes on the onset of CAD was also investigated. Results showed that hypertension is associated with late onset CAD (OR=0.656, 95% CI=0.504-0.853, p=0.001). Use of antihypertensive drugs showed a similar association with delayed CAD onset. When comparing age of onset in CAD patients with traditional risk factors such as hypertension, diabetes, hyperlipidemia, obesity, smoking and family history of CAD, the age of onset was significantly higher for patients with hypertension compared to those with any of the other risk factors studied (p < 0.001). In conclusion, hypertension and its treatment are associated with late coronary atherosclerotic manifestations in Lebanese population. This observation is currently under investigation to clarify its genetic and/or environmental mechanisms.

Mots clés: Hypertension; Coronary artery disease (CAD); Risk factors; Antihypertensive drugs; Therapeutic lifestyle changes; Lebanese population

Domaines: Génomique, Transcriptomique et Protéomique [q-bio.GN]

Aline Milane, Jad Abdallah, Roy Kanbar, Georges Khazen, Michella Ghassibe-Sabbagh, et al.. Association of hypertension with coronary artery disease onset in the Lebanese population.. SpringerPlus, 2014, 3, pp.533. ⟨10.1186/2193-1801-3-533⟩. ⟨inserm-01073038⟩