Université Paris-Saclay (Espace Technologique, Bat. Discovery - RD 128 - 2e ét., 91190 Saint-Aubin - France)
Abstract : Three independent pseudoautosomal loci are linked to sex determination at frequencies which define a gradient of linkage. The segregation patterns of these loci indicate that X/Y recombination results from a single obligatory meiotic crossing-over in the pseudoautosomal region. Recombination in male germ cells in the terminal regions of the short arms of the X and Y chromosomes in 10-fold greater than between the same regions of the X chromosomes in female germ cells.
F Rouyer, M C Simmler, C Johnsson, Gilles Vergnaud, H J Cooke, et al.. A gradient of sex linkage in the pseudoautosomal region of the human sex chromosomes.. Nature, Nature Publishing Group, 1996, 319 (6051), pp.291-5. ⟨hal-01160710⟩