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Journal articles
3D map of theranostic nanoparticles distribution in mice brain and liver by means of X-ray Phase Contrast Tomography
E. Longo
1
A. Bravin
2
F. Brun
3
I. Bukreeva
3
A. Cedola
3
M. Fratini
3
X. Le Guevel
4
L. Massimi
3
L. Sancey
4
O. Tillement
5
P. Zeitoun
1
O. de La Rochefoucauld
6
1
LOA - Laboratoire d'optique appliquée (828, boulevard des Maréchaux 91762 Palaiseau Cedex - France)
- CNRS - Centre National de la Recherche Scientifique : UMR7639 (France)
- X - École polytechnique (École polytechnique, 91128 Palaiseau Cedex - France)
- ENSTA Paris - École Nationale Supérieure de Techniques Avancées (828, boulevard des Maréchaux 91762 Palaiseau Cedex - France)
2
ESRF - European Synchrotron Radiation Facility (6 rue Jules Horowitz BP220 38043 GRENOBLE CEDEX - France)
4
IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (Institut pour l'Avancée des Biosciences
Centre de Recherche UGA / Inserm U 1209 / CNRS UMR 5309
Site Santé - Allée des Alpes
38700 La Tronche - France)
- CHU - Centre Hospitalier Universitaire [Grenoble] (CS 10217 38043 Grenoble cedex 9 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1209 (101, rue de Tolbiac, 75013 Paris - France)
- EFS - Etablissement français du sang - Auvergne-Rhône-Alpes (France)
- CNRS - Centre National de la Recherche Scientifique : UMR5309 (France)
- UGA - Université Grenoble Alpes (CS 40700 - 38058 Grenoble cedex - France)
5
ILM - Institut Lumière Matière [Villeurbanne] (UMR5306 CNRS Université Claude Bernard Lyon 1 Domaine Scientifique de La Doua Bâtiment Kastler, 10 rue Ada Byron 69622 Villeurbanne CEDEX, Franc - France)
- UCBL - Université Claude Bernard Lyon 1 (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)
- Université de Lyon (92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR5306 (France)
6
Imagine Optic (France)
Abstract : The word "theranostic" derives from the fusion of two terms: therapeutic and diagnostic. It is a promising research field that aims to develop innovative therapies with high target specificity by exploiting the therapeutic and diagnostic properties, in particular for metal-based nanoparticles (NPs) developed to erase cancer. In the framework of a combined research program on low dose X-ray imaging and theranostic nanoparticles (NPs), high resolution Phase-Contrast Tomography images of mice organs injected with gadolinium and gold-NPs were acquired at the European Synchrotron Radiation Facility (ESRF). Both compounds are good X-ray contrast agents due to their high attenuation coefficient with respect to biological tissues, especially immediately above K-edge energy. X-ray tomography is a powerful non-invasive technique to image the 3D vasculature network in order to detect abnormalities. Phase contrast methods provide more detailed anatomical information with higher discrimination among soft tissues. We present the images of mice liver and brain injected with gold and gadolinium NPs, respectively. We discuss different image processing methods used aiming at enhancing the accuracy on localizing nanoparticles.
Complete list of metadatas
https://hal-ensta-paris.archives-ouvertes.fr//hal-01774166
Contributor : Pierre Zaparucha <>
Submitted on : Monday, April 23, 2018 - 2:37:42 PM
Last modification on : Thursday, April 2, 2020 - 10:48:04 AM
Contributor : Pierre Zaparucha <>
Submitted on : Monday, April 23, 2018 - 2:37:42 PM
Last modification on : Thursday, April 2, 2020 - 10:48:04 AM
Identifiers
- HAL Id : hal-01774166, version 1
- DOI : 10.1088/1748-0221/13/01/C01049
Collections
ENSTA | CNRS | X-LOA | ENSTA_LOA | X | UNIV-LYON1 | UNIV-PARIS-SACLAY | X-DEP-PHYS | ILM | UDL
Citation
E. Longo, A. Bravin, F. Brun, I. Bukreeva, A. Cedola, et al.. 3D map of theranostic nanoparticles distribution in mice brain and liver by means of X-ray Phase Contrast Tomography. Journal of Instrumentation, IOP Publishing, 2018, 13 (01), pp.C01049 - C01049. ⟨10.1088/1748-0221/13/01/C01049⟩. ⟨hal-01774166⟩
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