Palladium‐Catalyzed C8‐Oxygenation of Naphthalene Derivatives: Direct Access to Naphtholactone Skeleton - ENSTA Paris - École nationale supérieure de techniques avancées Paris Accéder directement au contenu
Article Dans Une Revue Advanced Synthesis and Catalysis Année : 2021

Palladium‐Catalyzed C8‐Oxygenation of Naphthalene Derivatives: Direct Access to Naphtholactone Skeleton

Résumé

Herein, a direct C8-oxygenation of naphthalene derivatives is described. Different carbonyl groups were used as directing group to deliver corresponding naphthols via a palladium-catalyzed oxidation reaction using PhI(OAc)2 in a TFA/TFAA mixture. Interestingly, when Weinreb amide was employed as the directing group, the naphtholactone skeleton was directly obtained. This methodology was applied to the synthesis of variously substituted naphtholactones.
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Dates et versions

hal-03307182 , version 1 (23-08-2021)

Identifiants

Citer

Caroline Berrou, Sébastien Prévost. Palladium‐Catalyzed C8‐Oxygenation of Naphthalene Derivatives: Direct Access to Naphtholactone Skeleton. Advanced Synthesis and Catalysis, In press, 363 (16), pp.4091-4095. ⟨10.1002/adsc.202100317⟩. ⟨hal-03307182⟩
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