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Article Dans Une Revue European Journal of Organic Chemistry Année : 2011

Carbohydrate-Porphyrin Conjugates with Two-Photon Absorption Properties as Potential Photosensitizing Agents for Photodynamic Therapy

Résumé

We report the synthesis of a series of conjugated zinc porphyrin oligomers designed as photodynamic therapy agents. These compounds exhibit exceptionally high two-photon absorption cross-sections, redshifted linear absorption spectra, and high singlet oxygen quantum yields, making them ideal for one-photon- and two-photon-excited photodynamic therapy. These products are substituted by three α-mannose units on each chromophore with the aim to target tumor cells with over-expressing lectin-type membrane receptors.

Dates et versions

hal-00875501 , version 1 (22-10-2013)

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Sylvain Achelle, Pierre Couleaud, Patrice L. Baldeck, Marie-Paule Teulade-Fichou, Philippe Maillard. Carbohydrate-Porphyrin Conjugates with Two-Photon Absorption Properties as Potential Photosensitizing Agents for Photodynamic Therapy. European Journal of Organic Chemistry, 2011, 2011 (7), pp.1271-1279. ⟨10.1002/ejoc.201001209⟩. ⟨hal-00875501⟩
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