High-Energy Charged Particles for Spatially Fractionated Radiation Therapy
Résumé
Spatially fractionated radiotherapy (SFRT) offers a gain in normal tissue sparing with
respect to standard seamless irradiations. The benefits of SFRT may be further enhanced
by replacing the commonly used photon beams by charged particles. Along this line,
proton SFRT has already shown a significant widening of the therapeutic window for
radioresistant tumors in preclinical studies. The goal of this work was to investigate
whether the use of superior energies as compared to the clinical ones, as well as heavy
ions could lead to a further improvement of SFRT. New facilities such as FAIR, RAON,
or some others associated with the International Biophysics collaboration will be able
to provide very intense high-energy ion beams, enabling the experimental evaluation of
the Monte Carlo simulations reported in this work. Our results indicate that proton SFRT
could benefit from the use of higher beam energies (1 GeV). Concerning heavy ions, ˜
such as carbon or neon, the main advantage would be the possible theragnostic use.
Biological experiments are needed to validate these results, and they will be the subject
of future experimental proposals at those new facilities