[Chronic intestinal pseudo-obstruction and anti-Hu syndrome: 13 years of follow-up without neoplasia]. - Archive ouverte HAL Access content directly
Journal Articles Gastroentérologie Clinique et Biologique / Research and Clinics in Hepatology and Gastroenterology Year : 2008

[Chronic intestinal pseudo-obstruction and anti-Hu syndrome: 13 years of follow-up without neoplasia].

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1
Audrey Amiot
  • Function : Author
F. Joly
  • Function : Author
B. Messing
  • Function : Author
A. Lavergne-Slove
  • Function : Author
J.-Y. Delattre
  • Function : Author
Y. Bouhnik
  • Function : Author

Abstract

Chronic intestinal pseudo-obstruction (CIPO) is a heterogeneous group of rare disorders characterised by symptoms of intestinal obstruction with no mechanical evidence of obstruction. It is caused by ineffective intestinal contractions due to visceral neuropathy and/or neuropathy. In adults, CIPO is mostly secondary. The most common causes are metabolic disorders, connective tissue disorders, neuropathic drug related injuries, paraneoplasic and post-infectious syndromes and amyloidosis. Secondary forms of CIPO have been reported with anti-Hu antibodies. This corresponds to an antineuronal antibody that recognizes a protein expressed in the nuclei of neuron (ANNA-1) and neoplasic cells. The anti-Hu antibody must be searched for in patients over 40 years old with CIPO (associated with small cell lung cancer in 75% of cases). Recently, the association of CIPO and the anti-Hu antibody has been described without associated neoplasia. We report a case of an association of CIPO and anti-Hu antibody without cancer after 13 years of follow-up.
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Dates and versions

hal-00815961 , version 1 (19-04-2013)

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Audrey Amiot, F. Joly, B. Messing, H. Sokol, A. Lavergne-Slove, et al.. [Chronic intestinal pseudo-obstruction and anti-Hu syndrome: 13 years of follow-up without neoplasia].. Gastroentérologie Clinique et Biologique / Research and Clinics in Hepatology and Gastroenterology, 2008, 32 (1 Pt. 1), pp.51-5. ⟨10.1016/j.gcb.2007.12.010⟩. ⟨hal-00815961⟩
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