Striatal circuits, habits, and implications for obsessive–compulsive disorder - Archive ouverte HAL Access content directly
Journal Articles Current Opinion in Neurobiology Year : 2015

Striatal circuits, habits, and implications for obsessive–compulsive disorder

(1) , (2) , (3) , , (4, 5)
1
2
3
4
5

Abstract

Increasing evidence implicates abnormalities in corticostriatal circuits in the pathophysiology of obsessive-compulsive disorder (OCD) and OC-spectrum disorders. Parallels between the emergence of repetitive, compulsive behaviors and the acquisition of automated behaviors suggest that the expression of compulsions could in part involve loss of control of such habitual behaviors. The view that striatal circuit dysfunction is involved in OC-spectrum disorders is strengthened by imaging and other evidence in humans, by discovery of genes related to OCD syndromes and by functional studies in animal models of these disorders. We highlight this growing concordance of work in genetics and neurobiology suggesting that frontostriatal circuits, and their links with basal ganglia, thalamus and brainstem, are promising candidates for therapeutic intervention in OCD.
Fichier principal
Vignette du fichier
Burguière_CurrOpNeurobiol_Submitted_7-6-14 (2).pdf (879.34 Ko) Télécharger le fichier

Dates and versions

hal-03095665 , version 1 (15-11-2022)

Identifiers

Cite

Eric Burguière, Patricia Monteiro, Luc Mallet, Guoping Feng, Ann Graybiel. Striatal circuits, habits, and implications for obsessive–compulsive disorder. Current Opinion in Neurobiology, 2015, 30, pp.59-65. ⟨10.1016/j.conb.2014.08.008⟩. ⟨hal-03095665⟩
6 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More