Striatal circuits, habits, and implications for obsessive–compulsive disorder

Eric Burguière (1) , Patricia Monteiro (2) , Luc Mallet (3) , Guoping Feng , Ann Graybiel (4, 5)

1 ICM - Institut du Cerveau = Paris Brain Institute
2 Unite de Recherches en Immunologie Humaine
3 ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute
4 McGovern Institute for Brain Research [Cambridge]
5 Department of Brain and Cognitive Sciences

Increasing evidence implicates abnormalities in corticostriatal circuits in the pathophysiology of obsessive-compulsive disorder (OCD) and OC-spectrum disorders. Parallels between the emergence of repetitive, compulsive behaviors and the acquisition of automated behaviors suggest that the expression of compulsions could in part involve loss of control of such habitual behaviors. The view that striatal circuit dysfunction is involved in OC-spectrum disorders is strengthened by imaging and other evidence in humans, by discovery of genes related to OCD syndromes and by functional studies in animal models of these disorders. We highlight this growing concordance of work in genetics and neurobiology suggesting that frontostriatal circuits, and their links with basal ganglia, thalamus and brainstem, are promising candidates for therapeutic intervention in OCD.

Mots clés: Striatal circuits; habits; and implications for obsessive-compulsive disorder Article Type: 30 Neuropsychiatry

Domaines: Sciences du Vivant [q-bio]

Eric Burguière, Patricia Monteiro, Luc Mallet, Guoping Feng, Ann Graybiel. Striatal circuits, habits, and implications for obsessive–compulsive disorder. Current Opinion in Neurobiology, 2015, 30, pp.59-65. ⟨10.1016/j.conb.2014.08.008⟩. ⟨hal-03095665⟩