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Journal articles
Mapping of a gene for long QT syndrome to chromosome 4q25-27.
J J Schott
1
F Charpentier
2
S Peltier
3
P Foley
4
E Drouin
5
J B Bouhour
P Donnelly
6
Gilles Vergnaud
7, 8
L Bachner
J P Moisan
E Drouin 5
Author
J B Bouhour
Author
P Donnelly 6
Author
Gilles Vergnaud 7, 8
Mail :
Author IdHAL : gilles-vergnaud ResearcherId : http://www.researcherid.com/rid/P-1304-2015 ORCID : https://orcid.org/0000-0003-0913-194X
L Bachner
Author
J P Moisan
Author
1
ITX - unité de recherche de l'institut du thorax UMR1087 UMR6291 (8 quai Moncousu - BP 70721 - 44007 Nantes Cedex 1 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1087 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR6291 (France)
- UFR MEDECINE - Université de Nantes - UFR de Médecine et des Techniques Médicales (1 rue Gaston Veil BP 53508 44035 NANTES Cedex 1 - France)
- UN - Université de Nantes (1, quai de Tourville - BP 13522 - 44035 Nantes cedex 1 - France)
2
I2M - Institut de Mécanique et d'Ingénierie de Bordeaux (F-33400 Talence - France)
- INRA - Institut National de la Recherche Agronomique : USC1368 (France)
- UB - Université de Bordeaux (35, place Pey Berland - 33076 Bordeaux - France)
- ENSAM - École Nationale Supérieure d'Arts et Métiers (France)
- Arts et Métiers Sciences et Technologies (151 boulevard de l'Hôpital 75013 Paris - France)
- HESAM - HESAM Université (15, rue Soufflot 75005 Paris - France)
- Arts et Métiers Sciences et Technologies (151 boulevard de l'Hôpital 75013 Paris - France)
- Institut Polytechnique de Bordeaux (146, rue Léo Saignat, 33076 Bordeaux - France)
- CNRS - Centre National de la Recherche Scientifique : UMR5295 (France)
3
Université de Poitiers (15, rue de l'Hôtel Dieu - 86034 Poitiers Cedex - France)
4
INERIS - Institut National de l'Environnement Industriel et des Risques (Verneuil-en-Halatte ; Nancy ; Aix en Provence - France)
5
Tumeurs endocrines digestives : mécanismes de la tumorigenèse et de la progression tumorale (Faculte de medecine lyon-rth laennec 7, rue guillaume paradin 69372 LYON CEDEX 08 - France)
- UCBL - Université Claude Bernard Lyon 1 (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)
- Université de Lyon (92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U865 (101, rue de Tolbiac, 75013 Paris - France)
6
Department of Statistics [Oxford] (1 South Parks Road, Oxford OX1 3TG, UK - United Kingdom)
- University of Oxford [Oxford] (Wellington Square, Oxford OX1 2JD - United Kingdom)
7
IGM - Institut de génétique et microbiologie [Orsay] (Bâtiments 400 et 409
UFR des Sciences - Université Paris-Sud 11
15, rue Georges Clémenceau - F 91405 ORSAY Cedex - France)
- UP11 - Université Paris-Sud - Paris 11 (Bâtiment 300 - 91405 Orsay cedex - France)
- CNRS - Centre National de la Recherche Scientifique : UMR8621 (France)
8
ENSTA Paris - École Nationale Supérieure de Techniques Avancées (828, boulevard des Maréchaux 91762 Palaiseau Cedex - France)
Abstract : Long QT syndrome (LQTS) is a heterogeneous inherited disorder causing syncope and sudden death from ventricular arrhythmias. A first locus for this disorder was mapped to chromosome 11p15.5. However, locus heterogeneity has been demonstrated in several families, and two other loci have recently been located on chromosomes 7q35-36 and 3p21-24. We used linkage analysis to map the locus in a 65-member family in which LQTS was associated with more marked sinus bradycardia than usual, leading to sinus node dysfunction. Linkage to chromosome 11p15.5, 7q35-36, or 3p21-24 was excluded. Positive linkage was obtained for markers located on chromosome 4q25-27. A maximal LOD score of 7.05 was found for marker D4S402. The identification of a fourth locus for LQTS confirms its genetic heterogeneity. Locus 4q25-27 is associated with a peculiar phenotype within the LQTS entity.
Document type :
Journal articles
Complete list of metadatas
https://hal-ensta-paris.archives-ouvertes.fr//hal-01160657
Contributor : Gilles Vergnaud <>
Submitted on : Saturday, June 6, 2015 - 4:51:49 PM
Last modification on : Friday, June 19, 2020 - 2:06:03 PM
Contributor : Gilles Vergnaud <>
Submitted on : Saturday, June 6, 2015 - 4:51:49 PM
Last modification on : Friday, June 19, 2020 - 2:06:03 PM
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Identifiers
- HAL Id : hal-01160657, version 1
- PUBMED : 7485162
- PUBMEDCENTRAL : PMC1801360
Collections
ENSTA | CNRS | UNIV-POITIERS | INERIS | UNIV-NANTES | I2BC | INRA | UNIV-LYON1 | THORAX-UMR | I2M-BX | UDL | INRAE | ARTS-ET-METIERS-SCIENCES-ET-TECHNOLOGIES
Citation
J J Schott, F Charpentier, S Peltier, P Foley, E Drouin, et al.. Mapping of a gene for long QT syndrome to chromosome 4q25-27.. American Journal of Human Genetics, Elsevier (Cell Press), 1995, 57 (5), pp.1114-22. ⟨hal-01160657⟩
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