A deletion map of the human Y chromosome based on DNA hybridization.

Abstract : The genomes of 27 individuals (19 XX males, two XX hermaphrodites, and six persons with microscopically detectable anomalies of the Y chromosome) were analyzed by hybridization for the presence or absence of 23 Y-specific DNA restriction fragments. Y-specific DNA was detected in 12 of the XX males and in all six individuals with microscopic anomalies. The results are consistent with each of these individuals carrying a single contiguous portion of the Y chromosome; that is, the results suggest a deletion map of the Y chromosome, in which each of the 23 Y-specific restriction fragments tested can be assigned to one of seven intervals. We have established the polarity of this map with respect to the long and short arms of the Y chromosome. On the short arm, there is a large cluster of sequences homologous to the X chromosome. The testis determinant(s) map to one of the intervals on the short arm.
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Submitted on : Saturday, June 6, 2015 - 5:52:12 PM
Last modification on : Thursday, October 10, 2019 - 11:36:02 AM

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Gilles Vergnaud, D C Page, M C Simmler, L Brown, F Rouyer, et al.. A deletion map of the human Y chromosome based on DNA hybridization.. American Journal of Human Genetics, Elsevier (Cell Press), 1986, 38 (2), pp.109-24. ⟨hal-01160709⟩

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