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Laser-plasma accelerator and femtosecond photon sources-based ultrafast radiation chemistry and biophysics

Abstract : The initial distribution of energy deposition triggered by the interaction of ionizing radiations (far UV and X rays, electron, proton and accelerated ions) with molecular targets or integrated biological systems is often decisive for the spatio-temporal behavior of radiation effects that take place on several orders of magnitude. This contribution deals with an interdisciplinary approach that concerns cutting-edge advances on primary radiation events, considering the potentialities of innovating strategies based on ultrafast laser science, from femtosecond photon sources to laser-driven relativistic particles acceleration. Recent advances of powerful TW laser sources (similar to 10(19) Wcm(-2)) and laser-plasma interactions providing ultrashort relativistic particle beams in the energy domain 2.5-150 MeV open exciting opportunities for the development of high-energy radiation femtochemistry (HERF). Early radiation damages being dependent on the survival probability of secondary electrons and radial distribution of short-lived radicals inside ionization clusters, a thorough knowledge of these processes involves the real-time probing of primary events in the temporal range 10(-14)-10(-11) s. In the framework of a closed synergy between low-energy radiation femtochemistry (LERF) and the emerging domain of HERF, the paper focuses on early phenomena that occur in the prethermal regime of low-energy secondary electrons, considering very short-lived quantum effects in aqueous environments. Ahigh dose-rate delivered by femtosecond electron beam (similar to 10(11)-10(13) Gy s(-1)) can be used to investigate early radiation processes in native ionization tracks, down to 10(-12) s and 10(-9) m. We explain how this breakthrough favours the innovating development of real-time nanodosimetry in biologically relevant environments and open new perspectives for spatio-temporal radiation biophysics. The emerging domain of HERF would provide guidance for understanding the specific bioeffects of ultrashort particle bunches. This domain represents also a prerequisite for the control of in vitro and in vivo irradiation at ultrahigh dose-rates or the investigation of ultrafast dose-fractionating phenomena.
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Contributor : Pierre Zaparucha <>
Submitted on : Tuesday, June 6, 2017 - 10:46:20 AM
Last modification on : Thursday, March 5, 2020 - 6:34:24 PM



Yann Gauduel. Laser-plasma accelerator and femtosecond photon sources-based ultrafast radiation chemistry and biophysics. Journal of Instrumentation, IOP Publishing, 2017, 12 (02), pp.C02048 - C02048. ⟨10.1088/1748-0221/12/02/C02048⟩. ⟨hal-01533211⟩



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